Timely administration of anti-snake venom (ASV) along with cardiorespiratory support is the only effective treatment available for neurotoxic snake bite. ASV administration. On arrival, 100 ml (10 vials) of anti-snake venom (ASV) should be added to 200 ml of normal saline and should be run over 30 to 50 minutes; Repeat dose of ASV can be administered within 30 minutes after the initial dose, if there is no improvement of neurological manifestations; however, no more than 20 vials of ASV should be used However, there is no universal consensus on the optimal dose and protocol of ASV administration. CONCLUSIONS: Total requirement of anti-snake venom correlated positively with degree of coagulation dysfunction at entry. Antivenom is the only effective antidote for snake venom. The administration of adrenaline and … Snake Venom Antiserum lyophilized is a refined and concentrated preparation of serum globulins for intravenous administration, containing equine immunoglobulin fragments F(ab') 2 , obtained from the plasma of healthy equines, hyperimmunized against venoms of above species of snakes. It is an essential element of treatment of systemic envenoming but may be insufficient on its own to save the patient’s life. Snake venom released fatty acids at different concentrations (0.1-5 mg/ml) of venom in a dose-dependent manner. ... the physician should carefully assess the need for re-treatment with CroFab® and use of any type of anticoagulant or anti-platelet drug. [3,4] ASV is the most effective when administered early enough to neutralize venom in the circulation before it reaches the target site. Do not use in cases of coral snake envenomation or snakes not indigenous to the US. Snake Bite: Clinical Profile and Evaluation of Effective Anti-Snake Venom Dose Asif Raza Bhatti, Arshad Iqbal Satti , Muhammad Ali Khalid Department of Medicine, DHQ Teaching Hospital Rawalpindi. Venom induced coagulopathy takes time to reverse. Recognition of these signs and symptoms should prompt the use of antivenom. The present study proved that anti-snake venom is effective and an eventual antivenom reaction can be easily managed through a proper approach. Anti Snake Venom is a generic medicine name and there are several brands available for it. In one study involving 105 patients, low dose adrenaline given subcutaneously, immediately before administration of antivenom to snakebite victims significantly reduced the incidence of acute adverse reactions 10. Tariang D D, Philip P J, Alexander G, Macaden S, Jeyaseelan L, Peter J V, Cherian A M. Randomized controlled trial on the effective dose of anti-snake venom in cases of snake bite … Sat Dec 22, 2007. In allergic or sensitive patients, it is better to inject the Anti-Snake Venom Serum under cover of anti-histamines and hydrocortisone (100 mg.) intramuscularly 15 to 30 minutes before the administration of Anti-Snake Venom Serum. Do not use for Anavip administration, as it will result in incorrect dosing. Results: Of 88 patients with brown snake envenoming admitted over the 10 years, at least 35 had severe envenoming. In addition to antivenom, additional medical measures, including administration of other drugs, artificial respiration, kidney dialysis, wound care, reconstructive surgery and prosthesis as well as comprehensive rehabilitation services, are needed to effectively treat snakebite patients. North American Coral Snake Antivenin (Equine) is indicated only for the treatment of envenomation caused by bites of North American coral snakes - Micrurus (including the eastern and Texas varieties). Main outcome measure: The dose of antivenom required to neutralise venom, defined prospectively as the dose of antivenom given before the return of detectable fibrinogen levels. Clinical recovery takes time after antivenom administration and multiple vials do not speed recovery. Once the symptoms of the reaction have subsided, antivenom infusion can be completed. The Use of Rattlesnake (Crotaline) Antivenom. This ... of administration and duration of therapy. Some of the brands for anti snake venom might be better known than anti snake venom itself. An anti-H1 histamine blocker (such as IV chlorphenamine maleate, 10 mg in adults, 0.2 mg/kg in children) is given to combat released histamine. Hence patients having incoagulable blood at entry should be administered higher initial dose of ASV i.e., 150-200 ml. High-Dose Anti-Snake Venom Versus Low-Dose Anti- ... To asses the optimum dose of anti-snake venom to treat snake bites cases effectively. Antivenom may be expensive and in short supply. Dose CroFab® appropriately to gain and continue control of envenomation. Use only in cases of symptomatic crotalid snake envenomation (pit vipers including rattlesnakes, cottonmouths, and copperheads) in the US, for CroFab administration. Due to the danger of reactions the anti-snake venom should not be withheld by physicians from a snakebite victim, when indicated and appropriate guidelines should be followed for its administration. The mean dose requirement of anti-snake venom was 179.2 ml.